performance.io®

performance.io is a specialized SEO and AI search agency founded in 2017 by Matt Lowe, serving the pharmaceutical, biotechnology, and healthcare industries. The agency operates globally with offices in the United States, United Kingdom, Japan, and India, partnering with 15 of the world's top 20 pharmaceutical and biotech companies. The firm has built what it describes as the largest database of online performance in pharma and healthcare.

The agency focuses on three core service areas: SEO and AI search optimization, content marketing, and web analytics. A distinctive capability is their Generative Engine Optimization (GEO) service, which optimizes content for AI-powered search platforms like ChatGPT alongside traditional search engines. They also specialize in paywall SEO services, unlocking content creation potential previously hidden behind healthcare professional login portals.

performance.io has received multiple industry recognitions, including PM Digital Society's Agency Digital Team of the Year (2022) and consecutive Account Manager of the Year awards (2023, 2024). The agency maintains Great Place to Work certification and was a finalist for Agency Digital Team of the Year at the 2025 European Search Awards. Their client portfolio includes major pharmaceutical companies such as Sanofi, AstraZeneca, Novartis, and Novo Nordisk.

Organizations should consider performance.io when they need an agency with proven pharmaceutical industry expertise and a deep understanding of healthcare compliance requirements. The agency's track record with major pharma brands and their proprietary benchmarking data provide insights unavailable from generalist SEO firms.

Expect a data-driven approach focused on reducing reliance on paid channels and optimizing global domain strategies to minimize internal competition in search results. Their future-focused orientation toward AI search and GEO makes them suitable for organizations preparing for the evolving search landscape beyond traditional Google optimization.

performance.io exclusively serves the healthcare sector with particular concentration in pharmaceutical and biotechnology companies. The agency has developed specialized capabilities in compliant healthcare professional (HCP) content optimization, understanding the regulatory requirements that govern pharma marketing. They maintain expertise in optimizing content behind HCP login portals and have built proprietary benchmarking tools specific to pharma and healthcare online performance. The firm's client roster demonstrates sustained focus on this vertical, with major pharmaceutical brands including Sanofi, AstraZeneca, Novartis, GSK, and Novo Nordisk comprising their core business.

The ideal client is a pharmaceutical, biotechnology, or medical device company with annual revenues exceeding $500 million, operating in multiple international markets, and seeking to reduce marketing costs while improving organic search performance. They have complex content compliance requirements, particularly around healthcare professional audiences, and are looking to future-proof their digital strategy for AI-powered search platforms.