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Emerging Partner

ZettaYotta

Healthcare interoperability and FHIR solutions with cloud-native architecture

Middletown, Ohio, United States
Est. 2020
1-10 employees
Verified
6+ Yrs

About ZettaYotta

ZettaYotta, founded in 2020 as a division of ProKSys LLC, specializes in healthcare interoperability solutions and cloud-native healthcare technology. The company focuses on SMART on FHIR applications, data integration, and standards-based healthcare communication including HL7 v2.x, 3.0, FHIR, and X12 EDI.

The company offers a suite of cloud-deployable products designed for AWS and Azure environments, including zyEMPI (enterprise master patient index), zyFirefly (FHIR server), zyHEngine (HL7 interface engine), zyXEngine (X12 interface engine), zyGhost (AI-powered PHI de-identification), and zySCORE (quality scoring for regulatory compliance). All products are deployed via Terraform automation and can be customized through their marketplace.

ZettaYotta emphasizes adherence to FDA guidelines for Software as a Medical Device development and positions itself as adaptable to client methodologies, whether Agile or traditional SDLC. The company serves providers, payers, and healthcare technology startups with a focus on interoperability and cloud-based solutions.

Best For

Healthcare organizations seeking cloud-native interoperability solutions, particularly those needing FHIR integration, HL7 interface engines, or enterprise master patient indexing. Well-suited for organizations already operating in AWS or Azure environments who value infrastructure-as-code deployment and modular, customizable solutions.

Key Strengths

  • Comprehensive interoperability toolkit covering FHIR, HL7 v2.x/3.0, X12 EDI, and DICOM standards
  • Cloud-native architecture with automated Terraform deployment for AWS and Azure
  • Specialized EMPI solution designed for polyglot (multi-language) global applicability
  • FDA SaMD compliance expertise with regulatory-focused development approach
  • Modular product suite allowing organizations to implement specific components as needed
  • AI-powered PHI de-identification capabilities for data privacy and security

Why Choose ZettaYotta

Choose ZettaYotta if you need modern, cloud-native interoperability solutions with strong standards adherence and the flexibility to deploy in your own cloud infrastructure. Their approach is particularly relevant for organizations transitioning to FHIR-based architectures or building custom healthcare applications that require robust interface engines.

The company's emphasis on FDA SaMD compliance and modular architecture makes them suitable for healthcare technology companies developing regulated medical software, as well as established healthcare organizations modernizing their integration infrastructure with infrastructure-as-code practices.

Healthcare Focus

ZettaYotta is exclusively focused on healthcare technology, with particular expertise in providers, payers, revenue cycle management, and medical devices. Their product suite addresses core healthcare IT challenges including patient identity management (EMPI), clinical data exchange (FHIR/HL7), claims processing (X12 EDI), and PHI security. The company's adherence to FDA guidelines for Software as a Medical Device demonstrates commitment to healthcare regulatory requirements.

Their interoperability solutions support multiple healthcare standards essential for modern care coordination, including SMART on FHIR for application integration, C-CDA for clinical document exchange, and both 837/835 transactions for claims processing and 270/271 for eligibility verification.

Ideal Client Profile

Mid-sized healthcare organizations or health tech startups with cloud infrastructure expertise who need standards-based interoperability solutions. Organizations seeking to maintain control over their infrastructure while leveraging pre-built, modular components for FHIR, HL7, and EDI integration. Those developing Software as a Medical Device who value FDA compliance expertise.

Specializations

SMART on FHIR applications HL7 v2.x/3.0/FHIR interoperability Enterprise Master Patient Index (EMPI) NLP/NLU for clinical data Data integration pipelines (AWS/Azure) Software as a Medical Device (SaMD) X12 EDI transactions (837, 835, 270, 271)

Client Types

Hospitals Health Systems Payers Medical Devices Healthcare Startups

Why Choose ZettaYotta?

  • 6+ years of industry experience
  • 1-10 team members
  • Emerging Partner on Curatrix
  • Verified on Curatrix

Quick Facts

Headquarters
Middletown, Ohio, United States
Founded
2020
Company Size
1-10 employees

Profile last updated: Jan 24, 2026

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